Clinical and Laboratory Aspects of Thyroglobulin and Thyroglobulin Antibody in Differentiated Thyroid Carcinoma

Thyroglobulin (Tg) is a precursor for thyroid hormone, specifically synthesized by follicular cells upon stimulation the stimulating hormone (TSH). Damage to caused benign or malignant diseases cause release of Tg into circulation. Differentiated cancer (DTC) most common endocrine malignancy, which has an excellent prognosis if detected and treated early. This review describes clinical laboratory aspects AntiTg measurement in management DTC. The serum been used pre- post-operative significance role its low level can play diagnosis monitoring DTC as well prediction recurrence must be understood. may lead production different with novel immunogenic epitopes that induce TgAb synthesis. preoperative shown high predictive value DTC, while postoperative detection disease persistence recurrence. Despite importance management, presence interferes analysis measurement, thus limiting utility. There no established regarding at measurement. Available methods measuring should emphasize lower upper limits their detection, especially early detection. accurate pertinent follow-up patients, any suspicious results interpreted accordance findings view present possible assay interference.